Lymphocyte subsets reference values for healthy adults in Togo

Abstract

The aim of this study was to establish the lymphocyte subsets reference values for healthy adults in 
Togo. A total of 139 subjects 5(100 males, 39 females) with hematological normal ranges were selected 
among 1349 voluntary blood donors who were otherwise included in a parallel study to establish the 
hematological reference values in Togo. All of them were negative for HIV, HBV, HCV infections and 
malaria. The dual-platform method was used to perform lymphocyte subsets counts. Reference ranges 
by gender (males vs females) were as follows: total T-lymphocytes (1071-2850 cells/µl vs 1185-2600 
cells/µl), CD4-lymphocytes (595-1750 cells/µl vs 675-1650 cells/µl), CD8-lymphocytes (420-1300 cells/µl 
vs 450-1100 cells/µl), B-lymphocytes (160-558 cells/µl vs 153-700 cells/µl) and NK-lymphocytes (114-560 
cells/µl vs 105-550 cells/µl). The range of the CD4:CD8 ratio was 0.9-2.1 in males and 1.1-2.3 in females. 
The CD8 cells count was lower and CD4:CD8 ratio was higher in females than in males. The B
lymphocyte count was higher than the NK-lymphocyte count unlike some literature data.