Clinical diagnostic indices of hypertensive patients

Abstract

The aim of the study was to investigate the efficacy of the use of some clinical indices as diagnostic parameters 
of hypertension. Twenty (20) healthy, normotensive human subjects and twenty (20) hypertensive patients were 
subjected to diastolic (D) and systolic (S) blood pressure, body mass index (BMI), serum creatinine (C), serum 
magnesium (Mg2+), serum sodium (Na+), serum total cholesterol (Ch), serum triglyceride (T), aspartate 
aminotransferase (AST) and fasting blood sugar (FBS) analyses.  The experimental design is a single factor 
completely randomized design (CRD). Results recorded of the healthy human subjects and hypertensive 
patients, expressed as mean ± standard error (S.E) (unit) were as follows : (D) 75.6±1.7 and 98.11±0.9 (mmHg), 
(S) 120.52 ± 9.14 and 156.87 ± 11.23 (mmHg), (BMI) 15.3±0.7 and 27.01±1.7(kg/m2), (C)1.2 ± 0.1and 1.8 ± 0.2 
(mg/dl), (Mg2+) 2.4 ± 0.1 and 1.11±0.63 (mm/L), (Na+)138 ± 1.16 and 149± 0.23, (Ch) 175±1.2 and 225±8.1(mg/dl), (T) 
76±1.3 and 125±2.1(mg/dl), (AST) 12.18 ± 1.16 and 22.5 ± 2.16 (U/l), (FBS) 82.18 ± 9.16 and 98.87± 14.23 (mg/dl). 
The mean values of D, S, BMI, Na+, Ch, T, AST and FBS were significantly higher (p<0.05) : but those of Mg2+ 
were significantly lower (p<0.01) in hypertensive patients compared with healthy human subjects. Incidence of 
hypertension correlated positively and significantly (p<0.05) with significant increase (p<0.05) in S, D, BMI, FBS, 
AST, Ch, T, and Na+; and significant decrease (p<0.01) in Mg2+. The statistical regression and correlation 
between serum total cholesterol  and systolic blood pressure of hypertensive patients were significant (p<0.05), 
r = 0.975. Observed values of systolic blood pressure could be used with high precision to predict serum total 
cholesterol levels of  hypertensive patients.