The role of vital exhaustion in cardiovascular risk in open population of 25–64-year-old men in Russia/Siberia (WHO MONICA-Psychosocial Program)
Keywords:
Vital exhaustion, arterial hypertension,, myocardial infarction,, DRD4 gene, DAT gene.Abstract
Objective of the study was to elucidate prevalence rates of vital exhaustion (VE), its effects on
cardiovascular disease (CVD) risks, and genetic traits in open population of 25–64-year-old men in
Russia/Siberia (Novosibirsk). Random representative sample of 25–64-year-old men was studied in a
framework of WHO MONICA-Psychosocial Program (MOPSY). Maastricht Questionnaire (MQ) was used to
assess VE. Genotyping of VNTR polymorphisms in DRD4 and DAT genes was performed. All new cases of
arterial hypertension (AH), myocardial infarction (MI), and stroke were registered in people without CVD
from 1994 to 2008. Data showed that VE rate was 66.8% in study population. Hazard ratio was significantly
increased (AH: HR = 3.2; MI: HR = 2.7; stroke: HR = 3.2) in men with VE compared with VE-free individuals
during the first five years of observation. Multifactorial modeling showed that VE together with concomitant
social gradient determined development of AH, MI, and stroke in open male population. Allele 7 of DRD4
and genotype 9/9 of DAT gene were associated with high level of VE. Open population of men showed high
level of VE, predictor for risk of developing CVD. Vital exhaustion was significantly associated with certain
VNTR polymorphisms of DRD4 and DAT gens.
