A tumor selective chemotherapy. Can this be managed by an algorithm based on the non-Markovian population dynamics?
Keywords:
chemotherapy, population dynamics, drug-tumor selectivity.Abstract
A non-Markovian theory of population dynamics is to simulate the anti-cancer drug distribution between malignant
and the hosting normal cell pools. The model takes into account both the cell life span and the proliferation rate
differences. This new simulation approach looks promising for its potential to optimize a chemotherapeutic strategy
by choosing the scheme with a higher degree of the drug-tumor selectivity.The pre-test designed simulation mode
fits nicely the experimental data on Porphylleren-MC16 (PMC16) pharmacokinetics patterns including the allometric
plots revealed for this new medicinal porphyrined-fullerene nanoparticle possessing some anti-cancer potential and
intervening into the oxygen-independent ATP production mechanisms.
