Mean Platelet Volume (MPV) in Intensive Care Unit (ICU) Patients: Is it a useful parameter in assessing prediction for mortality?

Abstract

The aim of the study is to investigate MPV (mean platelet volume) showing platelet reactivity if it is 
associated with the severity of the critical illness or mortality in ICU patients. Study group (130 patients) 
was formed from survivor group (68 patients) and non-survivor group (62 patients). Platelet counts and 
MPV values were compared between two groups in the first five days of hospitalization. MPV correlation 
was studied with APACHE II score, age, haemoglobin level, duration in the ICU and as an independent 
risk factor in mortality. Mean age and APACHE scores were significantly higher in non-survivor group 
compared to survivor group (p<0.05). There was no significant difference between two groups according 
to MPV and platelet counts in first five days of hospitalization. There was a unique positive correlation 
between MPV and APACHE score (r: 0.34, p< 0.05). Only age was independent risk factor in mortality. In 
our study, we found positive correlation between severity of critical illness and MPV. However, there was 
no relation between MPV and mortality in heterogenic critical patients. Subgroup analysis of patients in 
ICU might be useful in assessing prediction for mortality.