Increase activity of serum total and prostatic acid phosphatase in rats exposed to gasoline vapours

Abstract

In this study, changes in the activities of serum total and prostatic acid phosphatase (TACP and PACP, 
respectively), alkaline phosphatase (ALP), gamma( )-glutamyltransferase (GGT) and testosterone level were 
assessed in male rats exposed wholly to 17.82.6cm3 hr-1kg-1m-3 day-1 of gasoline vapours (8 hours daily, 6 
days/week) for 20 weeks in exposure chambers. The results showed that exposure to gasoline vapours caused 
a significant increase (P < 0.05) in serum TACP, PACP, ALP, GGT and testosterone levels, by 74.12 ± 4.71, 74.00 
± 2.80, 53.00 ± 3.6, 87.17 ± 2.5 and 83.42 ± 5.2 percents, respectively, in male rats. Increase in serum acid and 
alkaline phosphatases, - glutamyltransferase and testosterone levels, observed in this study to be associated 
with exposure of male rats to gasoline vapours, is known to be implicated in various prostatic clinical 
conditions, including prostatic cancer.