Effect of human papilloma virus in HIV infected person: A mini review

Abstract

Human immunodeficiency virus (HIV) infected person has greater frequency and severity of human 
papilloma virus (HPV)-associated cervical dysplasia than uninfected person. One of the risk factors for HPV 
infection and subsequent neoplasia of lower genital tract is impaired cell mediated immunity like in HIV 
patients. There is no clear information about infection of HPV and HIV in the same cell, but there is 
evidence which indicates role of HIV on HPV at molecular level.  The impact of HPV on HIV is not also 
clearly understood. Currently, no data suggest that HPV acts differently in HIV positive person, but HPV 
persist in the lesion. Treatment for HPV in HIV patients involves both correction of immuno-suppression 
and combination of standard treatment use to clear HPV. HIV sero-positivity is known to be associated with 
an increased prevalence of ano-genital HPV infections in both sexes. Little is known whether HPV vaccine 
in HIV positive person can mount and maintain protective antibody titer against HPV infection. HIV positive 
women should undergo gynecological examination and vaccination against HPV genotypes to prevent the 
development of cervical cancer. The objective of this review is to indicate the interaction of HPV with HIV in 
modulating pathogenesis and disease progression in co-infected individuals.