It is time to adopt a strategy of routine some thrombophilias screening in women with a confirmed history of venous thromboembolism or recurrent fetal loss

Abstract

Vascular disease in pregnancy is a rare event. Inherited risk factors for vascular disease include factor 
V Leiden, prothrombin, methylenetetrahydrofolate reductase point mutations and Antithrombin, protein 
C and S deficiencies. Recent studies suggest that there is also a link between these inherited 
ththrombophilias and adverse pregnancy complications such as fetal loss as well as venous 
thromboembolism. Here we describe 2 young patients with cerebrovascular thrombotic events whose 
only risk factor was genetic thrombophilia. In patients, complete clinical evaluation and laboratory 
investigations, including a thrombophilia workup and full radiological assessment, were performed. 
Recently genetic thrombophilia was reported in association with venous thromboembolism and various 
complications of pregnancy. Although it is rare, thrombophilia must not be misdiagnosed.