Visfatin in hyperlipidemic female patients

Abstract

Hyperlipidemia was a modifiable major risk factor in primary and secondary prevention of cardiovascular 
diseases. In recent studies it was demonstrated that adipose tissue besides being a store of lipids, was a site 
that secrete bioactive proteins into the circulation, one of which was visfatin. In clinical trials visfatin levels 
were found to be related to lipid parameters and obesity. In our study, we intended to show the relation of 
visfatin with lipid profile and metabolic parameters. The study included 60 female patients and 20 age matched 
control subjects. As well as making physical and antropometric examinations, fasting plasma glucose and 
insulin, post prandal plasma glucose and insulin, lipid profile, uric acid, homocysteine, c-reactive protein and 
visfatin levels were measured in all female subjects. Hyperlipidemic group had significantly higher plasma 
visfatin levels than control group ( p  0.01). In hyperlipidemic patients positive correlation was found between 
triglyceride and visfatin levels and negative correlation between low density cholesterol and visfatin levels. 
Then we classified our patient group with an indirect measure of insulin resistance as homeostasis model 
assesment 2.7 and homeostasis model assesment  2.7. We found that the group with homeostasis model 
assessment 2.7 had significantly high triglyceride, postprandial glucose, post prandial insulin and visfatin 
levels ( p0.05). In conclusion, our data may point toward a role of visfatin in lipid parameters and insulin 
resistance.