Hypolipemic effects of methanolic extract of persea americana seeds in hypercholestrolemic rats

Authors

  • Asaolu, Samuel Sunday Author
  • Oyeyemi Ajibade Olugbenga Author

Keywords:

Hypercholestrolemic, hypolipidemia, methanolic, persea americana, doses

Abstract

In this study, our objective was to investigate the possible hypolipemic effect of Persea americana (PA) 
on hypercholestrolemic rats. Acute administration of cholesterol resulted in the elevation of total 
cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDLC), very low density 
lipoprotein cholesterol (VLDLC) and reduction in high density lipoprotein cholesterol (HDLC). However, 
treatment with various doses of the methanolic extract of the seeds of Persea americana caused a 
significant reduction in the levels of TC, TG, LDLC and VLDLC while the levels of HDLC increased 
significantly. These effects were dose dependent as marked changes were observed at the highest 
concentration (300mg/kg) of the methanolic extract of Persea americana seeds. It was concluded that 
Persea americana seeds showed an hypolipemic effect and may serve as possible alternative treatment 
for hyperlipemia and hypertension. 

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Published

2011-03-16

Issue

Vol. 2 No. 1 (2011): vol 2 issue 1 2011

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Hypolipemic effects of methanolic extract of persea americana seeds in hypercholestrolemic rats . (2011). International Journal of Medical Advances and Discoveries, 2(1), 124-126. https://kevinpage.org/index.php/IJMAD/article/view/1275